Prevent heartworm, kill fleas, plus treat and control other parasites in one application

Proven protection against the threat of fleas, heartworms, and intestinal parasites
in a single, easy-to-apply monthly application.

Imoxi Topical Solution for Dogs
How Imoxi Topical Solution provides trusted protection
Why broad-spectrum protection is important

Trusted Protection

Imoxi Topical Solution contains imidacloprid for proven flea control and moxidectin for trusted heartworm prevention and intestinal parasite control.

Transdermal moxidectin has a unique pharmacologic profile that provides benefits other formulations do not.

  • It is the only macrocyclic lactone formulation to be FDA-approved as safe and effective for dogs with circulating microfilariae.1
  • Moxidectin is the only macrocyclic lactone shown to protect against heartworm all month long in dogs.2
Siamese cat and golden retriever

Moxidectin, the active ingredient in Imoxi, has an extended half-life*

Following transdermal absorption, moxidectin concentrates in the fatty tissue, slowly releasing into the bloodstream, resulting in a long half-life.

Half-life comparison chart of macrocyclic lactones

Effective against a broad spectrum of parasites

Pet owners may not be aware of the parasites dogs and cats face. Here are some fast facts about the importance of broad-spectrum control.



  • Heartworms are transmitted through infected mosquitoes and cause coughing, sluggishness, and difficult breathing; however, some dogs show no signs at all.
  • Heartworms can be fatal if left untreated.
  • There is no treatment for heartworms in cats.


  • Fleas are found outdoors and inside and can cause dogs or cats to scratch, chew, bite, lose fur, and become restless.
  • Fleas you see are only the tip of the iceberg. Their family can infest homes, living in carpets, bedding, furniture, and flooring.
intestinal parasites

Intestinal Parasites

  • Intestinal parasites such as roundworms, hookworms, and whipworms are everywhere. Your dog may pick them up at dog parks, from other dogs, drinking from a public water bowl or pond, or even taking a walk through the neighborhood.
  • These worms can cause inflammation, anemia, diarrhea, and, in some pets, even death.
  • Some intestinal parasites can be a danger to the whole family! These zoonotic diseases can be transmitted from animals to humans. Anyone coming in contact with fecal-contaminated soil is at risk, especially infants, the elderly, or those with compromised immune systems.
sarcoptic mange

Sarcoptic Mange

  • Also known as scabies, these mites cause severe itchiness and a pimple-like rash in dogs.
  • Sarcoptic mange is extremely contagious among dogs and can be transmitted from animals to humans.
ear mite

Ear Mites

  • Ear mites in cats can be picked up from the environment or other pets.
  • Signs in cats include shaking of the head, ear scratching, inflammation of the ear canals, and large accumulations of earwax.

IMPORTANT SAFETY INFORMATION: CAUTION: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian. Dogs: WARNING: DO NOT ADMINISTER THIS PRODUCT ORALLY. For the first 30 minutes after application, ensure that dogs cannot lick the product from application sites on themselves or other treated animals. Children should not come in contact with the application sites for two (2) hours after application. (See Contraindications, Warnings, Human Warnings and Adverse Reactions for more information.) Cats: Do not use on sick, debilitated, or underweight cats. Avoid oral ingestion. For full prescribing information, visit


  1. Freedom of Information Summary. NADA 141-251 Supplement. Oct. 24, 2013.
  2. Bowman, D.D., Ohmes, C.M., Hostetler, J.A. et al. Efficacy of 10% imidacloprid + 2.5% moxidectin topical solution (Advantage Multi® for Dogs) for the prevention of heartworm disease and infection all month long. Parasites Vectors 10, 478 (2017).
  3. Kojima, K., Yamamoto, K., Katae, H., et al. (1987). Bioavailability of oral ivermectin in dogs. Jpn J Vet Sci. 49(5):899-900.
  4. SENTINEL® Spectrum [Summary of Product Characteristics]. Frimley, Camberley, Surrey, UK: Novartis Animal Health UK Ltd.; May 2008 revision.
  5. Sarasola, P., Jernigan, A.D., Walker, D.K., et al. (2002). Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs. J Vet Pharmacol Therap. 25(4): 265-272.
  6. Data on file. Bayer.